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Updated: Jun 21, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Locked nucleic acid nucleoside triphosphates and polymerases: on the way towards evolution of LNA aptamers
Rakesh N Veedu1, Jesper Wengel
1Department of Physics and Chemistry, Nucleic Acid Center, University of Southern Denmark, Campusvej 55, Odense M, Denmark.
Abstract:
Among numerous nucleic acid analogs reported in the past decades, locked nucleic acid (LNA) has received substantial attention and has become a significant tool within chemical biology disciplines like molecular biology research, diagnostics and therapeutic development. However, despite their obvious structurally unique properties, LNA-based aptamers for diagnostic and therapeutic applications remain largely unexplored. Future evolution of LNA oligonucleotide aptamers will depend on scientific breakthroughs relating to enzymatic polymerization using LNA nucleoside triphosphates as substrates. Herein, we highlight recent developments in this direction using various polymerases.
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