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Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Overview of Systemic Arteries01:11

Overview of Systemic Arteries

The human body is a complex, well-organized machine, and at the heart of its operations lies the circulatory system. This network of blood vessels, which includes systemic arteries, plays a vital role in maintaining life by transporting nutrients, oxygen, and waste products to and from cells throughout the body.
Systemic circulation is the part of the cardiovascular system that carries oxygenated blood away from the heart to the body's tissues and returns deoxygenated blood back to the heart.
The Arch of Aorta01:10

The Arch of Aorta

The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
Arteries and Arterioles01:16

Arteries and Arterioles

Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles and...
Anatomy of Blood Vessels01:20

Anatomy of Blood Vessels

The vascular system, an integral part of the circulatory system, comprises various blood vessels that play crucial roles in maintaining the body's homeostasis. These blood vessels form a complex and efficient circulatory network. The three primary categories of blood vessels are the arteries, veins, and capillaries.
Arteries
Arteries circulate oxygenated blood from the heart, except the pulmonary artery, which transports deoxygenated blood to the lungs. Large arteries, such as the aorta, have...
Structure of Blood Vessels01:15

Structure of Blood Vessels

Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...

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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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An object-oriented modelling framework for the arterial wall.

M I Balaguera1, J C Briceño, J A Glazier

  • 1University of Los Andes, Bogotá, Colombia. manuel.balaguera@javeriana.edu.co

Computer Methods in Biomechanics and Biomedical Engineering
|July 16, 2009
PubMed
Summary
This summary is machine-generated.

A novel object-oriented framework enables customizable arterial wall models using imaging technology. This innovative approach accurately simulates arterial biomechanics, closely matching experimental data.

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Area of Science:

  • Biomedical Engineering
  • Computational Mechanics
  • Cardiovascular Research

Background:

  • Existing arterial wall models lack detailed structural mapping with microstructural data.
  • There is a need for advanced computational frameworks to simulate arterial biomechanics accurately.
  • Imaging technology offers potential for creating patient-specific vascular models.

Purpose of the Study:

  • To introduce a novel object-oriented modeling framework for the arterial wall.
  • To enable the generation of customizable artery models by integrating imaging technology.
  • To implement and verify the framework through simulations of arterial segment deformation.

Main Methods:

  • Development of an object-oriented modeling framework for the arterial wall.
  • Implementation of a matrix structural mechanics simulator for deformation analysis.
  • Generation of a model of an arterial segment, focusing on the tunica adventitia's passive behavior.
  • Conducting axial loading and pressure-volume simulations with sensitivity analysis.

Main Results:

  • The object-oriented framework successfully generated a customizable arterial segment model.
  • Simulations of axial loading and pressure-volume tests closely reproduced experimental control data both qualitatively and quantitatively.
  • Sensitivity analysis identified optimal parameter combinations for accurate biomechanical simulations.

Conclusions:

  • The presented object-oriented modeling framework is the first of its kind for the arterial wall.
  • The framework allows for detailed structural mapping with arterial microstructure, surpassing existing models.
  • The validated simulator accurately predicts arterial wall deformation, offering a powerful tool for cardiovascular research.