Hyperbranched polyamidoamines containing beta-cyclodextrin for controlled release of chlorambucil
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Updated: Jun 21, 2026

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
Published on: February 17, 2023
Yuanyuan Zhou1, Zhe Guo, Yongwen Zhang
1School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Abstract:
This work is focused on the controlled drug release behavior of hyperbranched HPMA in the presence of beta-CD. Hence, three HPMA-beta-CDs and a pure HPMA were synthesized by Michael addition polymerization. As a model drug, CLB (an anti-cancer drug) was loaded into them via a solution method for in vitro release studies. The DSC results indicate that the CLB/polymer interactions are at the molecular level. Loading CLB into these polymers results in an evident increase in their glass transition temperatures, and DeltaT(g) depends on the beta-CD content. The controlled-release experiments show that the presence of beta-CD can appropriately slow the release of CLB from HPMA-beta-CDs and adjust the ratio of CLB released in total drug loading.
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