Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 21, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Modeling an electronic conductor based on natural peptide sequences.

Francisco Rodríguez-Ropero1, David Zanuy, Xavier Assfeld

  • 1Departament d'Enginyeria Quimica, ETS d'Enginyeria Industrial de Barcelona, Universitat Politecnica de Catalunya, Barcelona E-08028, Spain. francisco.rodriguez-ropero@upc.edu

Biomacromolecules
|July 17, 2009
PubMed
Summary

Researchers designed a protein-based nanotube with a synthetic amino acid, creating a stable pi-stacking ladder. This structure facilitates charge transfer, showing potential for use as a molecular nanowire.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing electro-responsive glyoxal-crosslinked alginate hydrogel for the electrochemical detection of NADH and antibacterial activity in smart dressing biointerfaces.

International journal of biological macromolecules·2026
Same author

Proximal junctional kyphosis and failure risk around the thoracolumbar junction: Impact of anterior malalignment, pelvic retroversion, and upper instrumented level selection.

Brain & spine·2026
Same author

Corrigendum: Biomimetic engineering of conductive curli protein films (2018<i>Nanotechnology</i>29 454002).

Nanotechnology·2026
Same author

Three-Dimensional Magnetoelectric Nanocomposite GelMA Hydrogels for Wireless Electrical Stimulation of Cardiac Cells.

ACS applied materials & interfaces·2026
Same author

Idiopathic Thoracolumbar Scoliosis Treated at Adult Age: Timing of Surgery and Quality of Life.

Spine·2026
Same author

Biological evaluation of amidine derivatives: In vitro cytotoxicity and cellular antioxidant capacity.

PloS one·2026

Area of Science:

  • Biomolecular Engineering
  • Nanotechnology
  • Computational Chemistry

Background:

  • Protein-based nanostructures offer unique properties for advanced applications.
  • Synthetic amino acids can be incorporated to tailor material characteristics.
  • Understanding charge transfer in nanostructures is crucial for electronic applications.

Purpose of the Study:

  • To investigate the formation of a pi-stacking ladder and charge transfer in a protein-based tubular nanostructure.
  • To evaluate the stability and electronic properties of a nanotube modified with synthetic amino acids.
  • To explore the potential of this system as a molecular nanowire.

Main Methods:

  • Quantum mechanical (QM) calculations to determine conformational properties of beta-3-thienylalanine.

More Related Videos

Finite Element Modelling of a Cellular Electric Microenvironment
08:23

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Related Experiment Videos

Last Updated: Jun 21, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Finite Element Modelling of a Cellular Electric Microenvironment
08:23

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

  • Molecular dynamics (MD) simulations to assess nanotube stability and pi-stacking formation.
  • Quantum mechanics/molecular mechanics (QM/MM) calculations to analyze charge transfer in the oxidized nanotube.

    • Main Results:

    • Conformational analysis of beta-3-thienylalanine was performed.
    • Rational substitution of natural residues enhanced nanotube stability and formed an inner pi-stacking ladder.
    • QM/MM calculations confirmed delocalization of pi-electron deficiency, indicating charge transfer capabilities.

    Conclusions:

    • The designed protein-based nanotube exhibits enhanced stability and forms a pi-stacking ladder.
    • The delocalization of pi-electron deficiency suggests efficient charge transfer properties.
    • This engineered nanostructure is a promising candidate for molecular nanowire applications.