Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transition State Theory01:25

Transition State Theory

Transition-state theory, also known as activated-complex theory, provides a molecular-level explanation of reaction rates in both gas-phase and solution-phase reactions. It extends earlier kinetic models by considering the formation of a short-lived, high-energy configuration during a reaction.The progress of a chemical reaction can be represented using a reaction profile, which plots potential energy against the reaction coordinate. As two reactant molecules approach one another, their...
Propagation of Action Potentials01:23

Propagation of Action Potentials

The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Current Growth And Decay In RL Circuits01:30

Current Growth And Decay In RL Circuits

The current growth and decay in RL circuits can be understood by considering a series RL circuit consisting of a resistor, an inductor, a constant source of emf, and two switches. When the first switch is closed, the circuit is equivalent to a single-loop circuit consisting of a resistor and an inductor connected to a source of emf. In this case, the source of emf produces a current in the circuit. If there were no self-inductance in the circuit, the current would rise immediately to a steady...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Turning Off the Powerhouse: Mitochondria-Targeted DPPZ-Ru(II)/Ir(III)/Re(I) Complexes Trigger Dual Mitophagy and Apoptosis To Halt Triple-Negative Breast Cancer.

Journal of medicinal chemistry·2026
Same author

Dual functioning Ru(II)/Ir(III) complexes for ferroptosis and apoptosis in triple-negative breast cancer: a proof of concept by glutathione depletion.

Dalton transactions (Cambridge, England : 2003)·2025
Same author

Global Optimization of the Control Strategy of a Brownian Information Engine: Efficient Information-Energy Exchange in a Generalized Potential Energy Surface.

The journal of physical chemistry. A·2025
Same author

Performance of a Brownian information engine through potential profiling: Optimum output requisites, heating-to-refrigeration transition, and their re-entrance.

The Journal of chemical physics·2025
Same author

Achievable Information-Energy Exchange in a Brownian Information Engine through Potential Profiling.

The journal of physical chemistry. B·2025
Same author

Nonlinear stochastic differential equations: A renormalization group approach to direct calculation of moments.

Physical review. E·2025

Related Experiment Video

Updated: Jun 21, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Kramers-like turnover in load-dependent activated dynamics.

Debasish Mondal1, Pulak Kumar Ghosh, Deb Shankar Ray

  • 1Department of Physical Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India.

The Journal of Chemical Physics
|July 17, 2009
PubMed
Summary

External load impacts biological motor proteins by altering chemical reactions. A new model reveals a Kramers-like turnover in reaction rates, showing how load strength affects transport dynamics.

More Related Videos

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
07:41

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

Published on: June 5, 2017

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
08:08

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

Related Experiment Videos

Last Updated: Jun 21, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0
07:41

Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0

Published on: June 5, 2017

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
08:08

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

Area of Science:

  • Biophysics
  • Chemical Kinetics
  • Statistical Mechanics

Background:

  • Single-molecule experiments reveal external load effects on biological motor proteins.
  • Most studies focus on thermodynamically open systems, leaving a gap in understanding closed or coupled systems.

Purpose of the Study:

  • To analyze a prototype reaction model incorporating inertial Brownian motion and a viscous load.
  • To derive a general analytical expression for the rate constant under load.

Main Methods:

  • Modeled a particle in a force field undergoing inertial Brownian motion.
  • Coupled the particle to a viscous load with overdamped motion and harmonic coupling.

Main Results:

  • Derived a general analytical expression for the rate constant.
  • Demonstrated a Kramers-like turnover in the spatial diffusion-limited regime.
  • Showed that turnover depends on harmonic coupling strength and load drag coefficient.

Conclusions:

  • The model predicts a turnover phenomenon in reaction rates due to external load.
  • This turnover signifies a transition between zero-load and finite-load transport regimes.
  • The findings offer insights into load-dependent dynamics of molecular motors.