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Ocular involvement in paediatric haemolytic uraemic syndrome
Veit Sturm1, Marcel N Menke, Klara Landau
1Department of Ophthalmology, University Hospital of Zurich, Switzerland. veit_sturm@yahoo.com
Insights
Ocular complications are rare in paediatric haemolytic uraemic syndrome (HUS) but can be severe. Early detection of vision-threatening issues like Purtscher retinopathy is crucial for managing HUS patients.
Area of Science:
- Ophthalmology
- Pediatrics
- Nephrology
Background:
- Hemolytic uremic syndrome (HUS) is a serious condition in children.
- Ocular involvement in HUS is not well-documented.
- Understanding the frequency and severity of eye complications in pediatric HUS is important.
Observation:
- A retrospective study reviewed 87 pediatric HUS cases.
- Ocular involvement was identified in 3 out of 69 examined patients.
- Clinical findings included Purtscher retinopathy and isolated intraretinal hemorrhages.
Findings:
- Two patients presented with Purtscher retinopathy, one requiring laser photocoagulation for neovascularization.
- One patient had milder, isolated intraretinal hemorrhages.
- Severe cases resulted in decreased visual acuity due to optic nerve atrophy.
Implications:
- Ocular complications in pediatric HUS, though rare, can lead to significant vision loss.
- Physicians should be vigilant for potential eye issues in HUS patients.
- Prompt recognition and management are vital to prevent long-term visual impairment.
Purpose:
The aim of this study was to estimate the frequency and severity of ocular involvement in paediatric patients with haemolytic uraemic syndrome (HUS).
Methods:
The study was designed as an institutional, retrospective, observational case series. Charts for all 87 paediatric patients with HUS treated at the University Children's Hospital Zurich between 1995 and 2007 were reviewed. Patients with ocular involvement were identified and clinical findings presented.
Results:
Three of 69 examined patients with HUS showed ocular involvement. Ophthalmic findings in two children were consistent with bilateral Purtscher retinopathy, showing multiple haemorrhages, exudations and superficial retinal whitening. The third child presented with bilateral isolated central intraretinal haemorrhages as a milder form of ocular involvement. In one of the children with Purtscher retinopathy, laser photocoagulation was required for bilateral rubeosis irides and development of disc neovascularization. Longterm outcomes in the two severely affected children showed decreased visual acuity caused by partial atrophy of the optic nerves. In the milder case visual acuity was not impaired at any time.
Conclusions:
A minority of paediatric patients with HUS developed ocular involvement. Acute ocular findings varied in severity from isolated intraretinal haemorrhages to Purtscher-like retinopathy with retinal ischaemia. Longterm complications included the development of neovascularizations and consecutive optic nerve atrophy. Although ocular involvement in HUS seems to be rare, physicians should be aware of this complication because of its possible vision-endangering consequences.
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