Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thermal Safety of Forced-Air Warming During Balloon Occlusion in Isolated Perfusion Chemotherapy: A Prospective Feasibility Study Using Multisite Temperature Monitoring.

Cancers·2026
Same author

Anti-NMDAR encephalitis impairs intrinsic hippocampal dynamics through neuronal hypercoupling, hub dominance, and aberrant ensembles.

Molecular psychiatry·2026
Same author

Pharmacometric Analysis of Cafedrine/Theodrenaline Versus Ephedrine on Maternal Hemodynamics and Neonatal Acidosis During Cesarean Section.

Pharmaceutics·2026
Same author

Correction: Schmitz et al. Validation of the Palliative Care and Rapid Emergency Screening (P-CaRES) Tool in Germany. <i>J. Clin. Med.</i> 2025, <i>14</i>, 2191.

Journal of clinical medicine·2026
Same author

In utero exposure to NMDA receptor autoantibodies disrupts hippocampal circuit maturation.

Cell reports·2026
Same author

[Influence of airway management on the return of spontaneous circulation in out-of-hospital cardiac arrest: secondary analysis of a prospective multidevice study].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2026

Related Experiment Video

Updated: Jun 21, 2026

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

Basic life support with four different compression/ventilation ratios in a pig model: the need for ventilation.

Clemens Kill1, Alexander Torossian, Christian Freisburger

  • 1Department of Anaesthesiology and Critical Care, Philipps-University, D-35033 Marburg, Germany.

Resuscitation
|July 17, 2009
PubMed
Summary

A 100:5 compression to ventilation ratio during basic life support (BLS) is as effective as 30:2 for return of spontaneous circulation (ROSC). Ratios of 100:2 or compressions-only worsen oxygenation and decrease ROSC chances.

More Related Videos

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)
07:20

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: September 7, 2016

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation
10:55

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation

Published on: January 13, 2023

Related Experiment Videos

Last Updated: Jun 21, 2026

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)
07:20

Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)

Published on: September 7, 2016

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation
10:55

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation

Published on: January 13, 2023

Area of Science:

  • Cardiology
  • Emergency Medicine
  • Physiology

Background:

  • Basic life support (BLS) aims to oxygenate vital organs during cardiac arrest.
  • Current BLS guidelines recommend a 30:2 compression-to-ventilation ratio, but the optimal ratio remains under investigation.
  • This study evaluates different compression-ventilation ratios' effects on physiological parameters and resuscitation outcomes.

Purpose of the Study:

  • To compare the efficacy of four different compression-ventilation ratios (30:2, 100:5, 100:2, and compressions-only) during basic life support.
  • To assess the impact of these ratios on return of spontaneous circulation (ROSC), gas exchange, and cerebral tissue oxygenation.
  • To determine the optimal compression-ventilation strategy for improving outcomes in cardiac arrest.

Main Methods:

  • The study involved 32 pigs undergoing general anesthesia and endotracheal intubation.
  • Physiological monitoring included arterial and central venous lines, and continuous cerebral tissue oxygenation (PtiO2) monitoring.
  • Animals experienced induced cardiac arrest (ventricular fibrillation) followed by 10 minutes of BLS with randomized compression-ventilation ratios before Advanced Life Support (ALS).

Main Results:

  • Return of spontaneous circulation (ROSC) was observed in 50% of pigs with a 30:2 ratio and 62.5% with a 100:5 ratio.
  • A 100:2 ratio resulted in ROSC in 25% of pigs, while compressions-only yielded no ROSC.
  • The 100:5 and 100:2 ratios led to significantly higher PaCO2 levels compared to the 30:2 ratio during BLS.

Conclusions:

  • A compression-ventilation ratio of 100:5 appears to be as effective as the standard 30:2 ratio in achieving ROSC.
  • Compression-ventilation ratios of 100:2 or compressions-only negatively impact peripheral arterial oxygenation and reduce the likelihood of ROSC.
  • These findings suggest that modifying the compression-ventilation ratio may optimize BLS effectiveness.