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Published on: December 5, 2019
Elevated erythrocyte phospholipase A associated with Duchenne and myotonic muscular dystrophy
S L Iyer1, S S Katyare, J L Howland
1Committee on Biochemistry, Bowdoin College, Brunswick, Maine 04011, USA.
Abstract:
Erythrocytes from patients with Duchenne or myotonic muscular dystrophy exhibit substantially increased phospholipase A activity when compared to those from normal subjects. Incubation of dystrophic erythrocyte membranes with diphenylhydantoin lowers the phospholipase A activity to within normal limits while the drug does not diminish activity in membranes from normal cells. Elevated phospholipase A activity may be expected to lead to increased concentrations of lysophospholipids which may contribute to the membrane dysfunction shown to be associated with these diseases.
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