Calcium content of mice brain lipids during myelination

Calcium levels have been determined in brain of C57Bl mice and in the Quaking dysmyelinating mutant during the myelination period. In control mice, calcium content per gram brain is maximum at 20 days, at the acme of myelination, and decreases thereafter to reach a plateau at 30 days. This variation does not occur in the mutant where the level is 50% lower than maximum in controls and stable at 15 days after birth. In control mice, the variation may be related to the level or to the qualitative variation of some glycolipids and proteolipids as it disappears in lipid extract after Folch wash.