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Published on: January 18, 2019
Evidence for a nerve impulse-dependent GABA accumulation in the substantia nigra after treatment with
M P de la Mora1, K Fuxe, T Hökfelt
1Department of Histology, Karolinska Institutet, S-104 01 Stockholm, Sweden; Departemento de Biologia Experimental, Instituto de Biologia, Universidad Nacional Autónoma de México, Mexico 20 D.F. Mexico.
Abstract:
GABA accumulation was studied in the substantia nigra after treatment with L-glutamic acid-gamma-hydrazide (GAH) in rats 3 h following hemisection at the posterior hypothalamic level. GAH-induced GABA accumulation was significantly reduced on the hemisectioned side (P < 0.05, Wilcoxon's test). Two or three weeks after hemisection, glutamic acid decarboxylase activity was reduced in the substantia nigra of the hemisectioned side by 80%, showing that the descending GABA pathway to the substantia nigra had been transected. It is concluded that GAH-induced GABA accumulation might be nerve impulse-dependent.
