The effect of ouabain on the bioelectrical activity of extrapyramidal cortex and caudate nucleus in the rabbit brain

Bioelectrical activity of chronically implanted rabbits was studied after different doses of ouabain (0.25-1.5 microg) administered topically on the extrapyramidal cortex. The results indicate that the EEG effect of ouabain (relax pattern, epileptiform activity or spreading depression) depends on the dose employed. It is interesting that epileptiform activity appeared in the ipsilateral caudate nucleus during phenomena similar to the 'spreading depression' in the ipsilateral extrapyramidal cortex, i.e. in the site of ouabain administration.