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Updated: Jun 21, 2026

Remote Neuronal Activation Coupled with Automated Blood Sampling to Induce and Measure Circulating Luteinizing Hormone in Mice
Published on: August 25, 2023
Local degradation of luteinizing hormone-releasing hormone (LH-RH) in the rat central nervous system
E C Griffiths1, R Forbes, S L Jeffcoate
1Department of Physiology, Stopford Building, University of Manchester, Manchester M13 9PT, Great Britain.
Abstract:
Peptidases inactivating luteinizing hormone-releasing hormone (LH-RH) were found to be present in two subcellular fractions prepared from the following areas of the central nervous system of male and female rats: thalamus, hypothalamus, cortex and cerebellum. LH-RH immunoreactivity was also detected in these fractions after peptidase activity had been removed by heat denaturation. These findings support the concept that LH-RH may have a role in modulating neuronal activity within the central nervous system (CNS).
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