Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[The role of the heart-on-a-chip to drug evaluation].

Annales de biologie clinique·2026

Same author

Structure and molecular function of the BCL7 proteins.

Biochemical Society transactions·2026

Same author

N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease.

Translational neurodegeneration·2026

Same author

Blocking RAN translation without altering repeat RNAs rescues <i>C9ORF72</i>-related ALS and FTD phenotypes.

Science (New York, N.Y.)·2026

Same author

FTLD-MAPT mutations and short 5'UTR Tau mRNAs increase Tau translation.

NAR molecular medicine·2025

Same author

Structure of the nucleosome-bound human BCL7A.

Nucleic acids research·2025

Search research articles

Related Experiment Video

Updated: Jun 21, 2026

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

Published on: February 21, 2019

A minimally invasive microdevice for molecular sampling and analysis.

Marie-Line Cosnier¹, Franck Martin, Ali Bouamrani

¹Electronics and Information Technology Laboratory of the French Atomic Energy Commission Micro-Nano Technologies(CEA-LETI-MINATEC), 38054 Grenoble, France. marieline.cosnier@cea.fr

IEEE Transactions on Bio-Medical Engineering

|July 17, 2009

Summary

We developed a novel microdevice for minimally invasive biopsies, enhancing proteomic mass spectrometry analysis. This technology minimizes tissue damage and improves sample capture for cancer and neurodegenerative disease research.

More Related Videos

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Microbial DNA Analysis in the Field Using a Biological Extraction Field Kit and a Field qPCR Unit

Microbial DNA Analysis in the Field Using a Biological Extraction Field Kit and a Field qPCR Unit

Published on: January 2, 2026

Related Experiment Videos

Last Updated: Jun 21, 2026

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

Absorbent Microbiopsy Sampling and RNA Extraction for Minimally Invasive, Simultaneous Blood and Skin Analysis

Published on: February 21, 2019

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Microbial DNA Analysis in the Field Using a Biological Extraction Field Kit and a Field qPCR Unit

Microbial DNA Analysis in the Field Using a Biological Extraction Field Kit and a Field qPCR Unit

Published on: January 2, 2026

Area of Science:

Biomedical Engineering
Proteomics
Microtechnology

Background:

Minimally invasive biopsy techniques are crucial for reducing patient trauma.
Proteomic analysis requires high-quality tissue samples for accurate results.
Current biopsy methods can cause significant tissue damage, impacting downstream analysis.

Purpose of the Study:

To develop and present a new microdevice for minimally invasive biopsy.
To adapt the microdevice for proteomic mass spectrometry analysis.
To enhance tissue capture yield and specificity during biopsy procedures.

Main Methods:

Multidisciplinary collaboration integrating proteomics, cancer research, and microtechnology.
Manufacturing of a miniaturized biopsy device using microtechnology.
Incorporation of chemically functionalized areas for improved sample capture.

Main Results:

Successful development of a microdevice designed for minimally invasive biopsy.
Demonstrated potential for adaptation to proteomic mass spectrometry.
Enhanced capture yield and specificity achieved through functionalized areas.

Conclusions:

The developed microdevice offers a less invasive approach to tissue biopsy.
This technology has significant potential applications in cancer research and neurodegenerative disease studies.
The microdevice advances the integration of microtechnology with proteomic analysis.