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[Bilateral acute profound deafness after MMR vaccination--report of a case]
1Department of Otolaryngology, National Childrens' Hospital, Tokyo.
Abstract:
In April 1989 the MMR vaccination program had started, and until October, 1989, 630,000 children received vaccination. In is, however, well known that many children developed various complication including aseptic meningitis after vaccination, and the MMR vaccination program has discontinued. This report described a case of bilateral acute profound deafness most likely due to MMR vaccination. The cause of this deafness was presumed to be mumps vaccination. The bases of the presumption are as follows: the meningitis after MMR vaccination was elicited by PCR method to be caused by mumps vaccine, and the complication of CNS after measles vaccination occurs within 14 days after injection, while the onset of vomiting and gait disturbance of the case was 24 days after vaccination.
Insights
Measles, Mumps, and Rubella (MMR) vaccination can cause complications like aseptic meningitis. A case study suggests MMR vaccination, specifically the mumps component, may lead to acute profound deafness in children.
Area of Science:
- Pediatrics
- Immunology
- Neurology
Background:
- The Measles, Mumps, and Rubella (MMR) vaccination program was initiated in April 1989.
- The program was discontinued due to reported complications, including aseptic meningitis.
- Over 630,000 children received the MMR vaccine before its discontinuation.
Observation:
- A case of bilateral acute profound deafness potentially linked to MMR vaccination is reported.
- The patient experienced vomiting and gait disturbance 24 days post-vaccination.
Findings:
- PCR analysis identified the mumps vaccine as the cause of aseptic meningitis in a patient who received the MMR vaccine.
- Central nervous system complications following measles vaccination typically manifest within 14 days, contrasting with the case's 24-day onset.
Implications:
- This case highlights a potential rare adverse event associated with the mumps component of the MMR vaccine.
- Further investigation is warranted to understand the link between mumps vaccination and profound deafness.
- Understanding vaccine-related complications is crucial for public health and vaccination program safety.