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Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering
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Published on: July 10, 2016

Microfluidic enrichment of a target cell type from a heterogenous suspension by adhesion-based negative selection

James V Green1, Shashi K Murthy

  • 1Department of Chemical Engineering, Northeastern University, Boston, Massachusetts 02115, USA.

Lab on a Chip
|July 17, 2009
PubMed

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Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.