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Human extravillous trophoblast MHC class I expression is resistant to regulation by interferon-alpha
G Chumbley1, S Hawley, N P Carter
1Department of Pathology, University of Cambridge, U.K.
Journal of Reproductive Immunology
|September 1, 1991
Abstract:
We have shown that MHC Class I antigen expression by first trimester human extravillous trophoblast cells is resistant to upregulation by IFN-alpha while embryonic fibroblasts of the same gestational age are responsive. This is in contrast to our previous finding that IFN-gamma increases both Class I mRNA and surface expression in these trophoblast cells. It would appear that human trophoblast has differential susceptibility to the effects of the two classes of IFN.