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Updated: Jun 21, 2026

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Assaying the Ability of Diffusible Signaling Molecules to Reorient Embryonic Spinal Commissural Axons
Published on: March 8, 2010
Deal breaker: semaphorin and specificity in the spinal stretch reflex circuit
Géraldine S Maro1, Kang Shen, Hwai-Jong Cheng
1Departments of Biology and Pathology, Stanford University, Stanford, CA 94305, USA. gmaro@stanford.edu
Neuron
|July 18, 2009
Abstract:
Stretch reflex circuits are a prime example of wiring specificity in the vertebrate spinal cord. Homonymous sensory afferents and motoneurons typically form monosynaptic connections, while neurons innervating antagonistic or unrelated muscles do not. Pecho-Vrieseling et al. now show that the semaphorin Sema3E and its receptor Plexin-D1 prevent monosynaptic connectivity in the cutaneous maximus muscle stretch reflex circuit.

