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Updated: Jun 21, 2026

Human In-Vivo Bioassay for the Tissue-Specific Measurement of Nociceptive and Inflammatory Mediators
Published on: December 1, 2008
Anti-nociceptive and anti-inflammatory activity of sophocarpine
Yonglin Gao1, Guisheng Li, Chunmei Li
1College of Food Science and Engineering, Ocean University of China, Qingdao Shandong Province 266003, PR China.
Aim Of The Study:
This study aimed to assess the anti-nociceptive and anti-inflammatory activity of sophocarpine in rodents.
Materials And Methods:
The anti-nociceptive effect was evaluated in two experimental animal models and anti-inflammatory effect in three animal models, and sophocarpine was given by tail vein injection for the above study.
Results:
Pretreatment with a single dose of sophocarpine (20 and 40 mg/kg) produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. Pretreatment with a single dose of sophocarpine also produced significant dose-dependent anti-inflammatory effects on carrageenan-induced rat hind paw edema (15 and 30 mg/kg), xylene-induced mouse ear edema (20 and 40 mg/kg) and acetic acid-induced mouse vascular permeation (20 and 40 mg/kg).
Conclusions:
Sophocarpine possesses peripheral and central analgesic properties as well as anti-inflammatory activity on acute inflammatory processes.
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