Related Experiment Video
Updated: Aug 5, 2026

07:30
Learning Modern Laryngeal Surgery in a Dissection Laboratory
Published on: March 18, 2020
Leiomyosarcoma of the larynx
J M Chen1, W H Novick, C A Logan
1Department of Otolaryngology, McGill University, Montreal, Quebec, Canada.
The Journal of Otolaryngology
|October 1, 1991
Summary
Laryngeal leiomyosarcoma (LMS), a rare soft tissue sarcoma, can cause obstructive symptoms. Conservative surgery and irradiation effectively treated this case with no recurrence at 18 months.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Leiomyosarcoma (LMS) is a rare soft tissue sarcoma.
- LMS in the head and neck, particularly the larynx, is exceedingly uncommon.
- Early diagnosis and treatment are crucial for managing rare tumors.
Observation:
- A case of laryngeal leiomyosarcoma (LMS) presented with obstructive symptoms.
- The tumor's location in the larynx posed a diagnostic and therapeutic challenge.
- Initial symptoms included airway compromise due to tumor growth.
Findings:
- The laryngeal LMS was successfully treated with conservative surgical resection.
- Postoperative irradiation was administered to reduce the risk of recurrence.
- The patient remained disease-free at an 18-month follow-up evaluation.
Implications:
- This case highlights the possibility of laryngeal LMS, despite its rarity.
- Conservative surgical approaches combined with adjuvant radiotherapy can be effective.
- Effective management strategies for rare head and neck sarcomas are essential for improving patient outcomes.
Related Concept Videos
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Larynx
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids, corniculates, and...
Myasthenia Gravis ll: Pathophysiology
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Esophageal Achalasia
Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...

