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Updated: Aug 19, 2026
A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
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Histoacryl glue in microvascular surgery
W G Middleton1, W Matthews, D A Chiasson
1Department of Otolaryngology, University of Toronto, Wellesley Hospital, Ontario, Canada.
Abstract:
The use of Histoacryl glue in the performance of microvascular anastomosis was examined in a rat model. An improvement in efficiency as noted by the decreased ischemic time and diminished bleeding with clamp removal was noted. Histological examination of the anastomosis at one and three weeks revealed a mild foreign body type inflammatory response to glue and suture material with no media necrosis and only minimal fibrointimal proliferation.
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