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Updated: Jun 21, 2026

Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice
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The relation between open-field and emergence tests in a hyperactive mouse model.

R Lalonde1, C Strazielle

  • 1Centre Hospitalier de l'Université de Montréal/St-Luc, Unité de Recherche en Sciences Neurologiques, Montréal, Canada H2X 3J4. robert.lalonde@umontreal.ca

Neuropharmacology
|July 18, 2009
PubMed
Summary
This summary is machine-generated.

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Spontaneous hypertensive mice exhibit altered behaviors in open-field and emergence tests compared to controls. These findings suggest the emergence test may aid in screening therapies for attention deficit hyperactivity disorder (ADHD).

Area of Science:

  • Behavioral Neuroscience
  • Hypertension Research
  • Animal Models

Background:

  • Idiopathic hypertension is a complex condition often associated with behavioral alterations.
  • Spontaneous hypertensive mice (SHM) serve as a valuable model for studying hypertension and its comorbidities.

Purpose of the Study:

  • To investigate the relationship between open-field test behaviors and emergence test performance in spontaneous hypertensive mice (SHM).
  • To explore the potential utility of the emergence test in identifying behavioral phenotypes relevant to conditions like attention deficit hyperactivity disorder (ADHD).

Main Methods:

  • Behavioral assessments were conducted using open-field and emergence tests in young and aged SHM and normotensive controls.
  • Locomotor activity (segments crossed), rearing, grooming, and emergence latencies were quantified.

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Last Updated: Jun 21, 2026

Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice
07:12

Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice

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Novel Object Exploration as a Potential Assay for Higher Order Repetitive Behaviors in Mice
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Novel Object Exploration as a Potential Assay for Higher Order Repetitive Behaviors in Mice

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Main Results:

  • SHM displayed increased locomotion and rearing in the open-field compared to controls.
  • Grooming behavior was reduced in older SHM.
  • Emergence from a novel object was faster in older SHM, with correlations found between open-field activity and emergence latencies.
  • Grooming showed a positive correlation with emergence time.

Conclusions:

  • Behavioral differences observed in SHM suggest a link between hypertension and altered exploratory and anxiety-related behaviors.
  • The emergence test, particularly when correlated with open-field activity, shows promise as a screening tool for potential ADHD therapies.