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Related Experiment Video

Updated: Jun 21, 2026

Production of Haploid Zebrafish Embryos by In Vitro Fertilization
07:54

Production of Haploid Zebrafish Embryos by In Vitro Fertilization

Published on: July 14, 2014

Early zebrafish development: it's in the maternal genes.

Elliott W Abrams1, Mary C Mullins

  • 1University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology, 1211 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104-6058, United States.

Current Opinion in Genetics & Development
|July 18, 2009
PubMed
Summary

Maternal gene products control early embryonic development. Zebrafish mutants reveal key molecular mechanisms for vertebrate development, including polarity, egg activation, and germ cell formation.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • Early animal development relies on maternal gene products supplied during oogenesis.
  • Maternal regulation is crucial but understudied in vertebrates due to experimental challenges.
  • Zebrafish maternal-effect screens offer new insights into vertebrate developmental controls.

Purpose of the Study:

  • To review recent studies on maternal gene function in early vertebrate development.
  • To highlight molecular mechanisms controlling key developmental processes.
  • To discuss advances in understanding maternal control using zebrafish mutants.

Main Methods:

  • Analysis of 12 zebrafish maternal-effect mutant genes.
  • Investigating gene function in early embryonic development.

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Generation of Maternal Mutants Using zpc:cas9 Knock-in Zebrafish
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Generation of Maternal Mutants Using zpc:cas9 Knock-in Zebrafish

Published on: July 22, 2025

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
10:08

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

Published on: December 21, 2021

Related Experiment Videos

Last Updated: Jun 21, 2026

Production of Haploid Zebrafish Embryos by In Vitro Fertilization
07:54

Production of Haploid Zebrafish Embryos by In Vitro Fertilization

Published on: July 14, 2014

Generation of Maternal Mutants Using zpc:cas9 Knock-in Zebrafish
09:17

Generation of Maternal Mutants Using zpc:cas9 Knock-in Zebrafish

Published on: July 22, 2025

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
10:08

Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants

Published on: December 21, 2021

  • Focusing on processes like polarity, egg activation, and morphogenesis.

    • Main Results:

    • Identified maternal control mechanisms for animal-vegetal polarity.
    • Elucidated roles in egg activation and cleavage development.
    • Demonstrated importance in body plan formation, tissue morphogenesis, and germ cell development.
    • Highlighted the significance of microRNA regulation in maternal control.

    Conclusions:

    • Zebrafish mutants provide essential molecular entry points for studying maternal control in vertebrates.
    • These studies illuminate diverse aspects of early development regulated by maternal factors.
    • Further research on maternal gene function is critical for understanding developmental processes.