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Updated: Jun 21, 2026
07:40
Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
Published on: August 9, 2019
"Home sweet home" for lymphocytes.
Steven D Rosen1, Hanayo Arata-Kawai
1University of California, San Francisco, CA, USA.
Blood
|July 18, 2009
Summary
Researchers detailed the glycans on CD34, a ligand expressed by the human T-cell leukemia virus type 1 (HEV), from human tonsils. This deepens our understanding of how L-selectin facilitates lymphocyte homing.
Area of Science:
- Immunology
- Glycobiology
- Cellular Biology
Background:
- Lymphocyte homing is crucial for immune surveillance and is mediated by cell adhesion molecules like L-selectin.
- CD34 is a cell surface glycoprotein involved in hematopoietic stem cell homing and is expressed on various immune cells.
Discussion:
- This study presents a detailed glycan analysis of HEV-expressed CD34 from human tonsils.
- Understanding the specific glycan structures on CD34 can elucidate their role in L-selectin ligand interactions.
Key Insights:
- The analysis provides the most comprehensive glycomic profile of CD34 to date.
- Specific glycan structures identified may be critical for L-selectin binding and subsequent lymphocyte trafficking.
Outlook:
- Further research can explore the functional implications of these glycans in different immune cell subsets.
- This work may pave the way for therapeutic strategies targeting lymphocyte homing in inflammatory or autoimmune diseases.
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