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Related Experiment Video

Updated: Jun 21, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

[Primary esophageal melanoma].

Robin Rivera Irigoín¹, Víctor Aguilar Urbano, Juana Gonzalo Marín

¹Servicio de Aparato Digestivo, Hospital Costa del Sol, Marbella.

Revista De Gastroenterologia Del Peru : Organo Oficial De La Sociedad De Gastroenterologia Del Peru

|July 18, 2009

Summary

This summary is machine-generated.

Primary Esophageal Melanoma (PEM) is a rare and aggressive cancer. This report details two new cases, highlighting diagnostic methods and the challenging prognosis of this exceptional neoplasm.

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Last Updated: Jun 21, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

Area of Science:

Gastroenterology
Oncology
Pathology

Background:

Primary Esophageal Melanoma (PEM) is an exceptionally rare malignancy, with fewer than 270 documented cases globally.
PEM exhibits aggressive behavior and a poor prognosis, often presenting similarly to other esophageal tumors.

Observation:

Two new cases of PEM are presented, diagnosed via endoscopy and biopsy.
Immunohistochemical analysis (HMB-45 and S100 positive) confirmed the primary nature of the esophageal melanoma.
One case presented with an unusual early sign of left miosis without ptosis or enophthalmos.

Findings:

The first case's advanced stage precluded surgical excision due to thoracic artery involvement.
The second case, despite local extension and surgical resection, resulted in post-operative complications and mortality.
Diagnostic confirmation relied on endoscopic biopsies and specific melanoma markers.

Implications:

This report underscores the diagnostic challenges and aggressive nature of Primary Esophageal Melanoma.
Early detection and understanding of unique presentations like miosis are crucial for improved outcomes.
Further research into treatment strategies and prognostic factors for PEM is warranted given its rarity and severity.