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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Alternative splicing of transcription factors' genes: beyond the increase of proteome diversity

David Talavera1, Modesto Orozco, Xavier de la Cruz

  • 1Barcelona Science Park (PCB), Molecular Modelling and Bioinformatics Unit, Institute for Research in Biomedicine (IRB), 08028 Barcelona, Spain. talavera@ebi.ac.uk

Comparative and Functional Genomics
|July 18, 2009
PubMed

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Alternative RNA Splicing02:18

Alternative RNA Splicing

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There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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RNA Splicing

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General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...