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Results of a multilaboratory checksample analysis program for carbon monoxide and cyanide
1College of Pharmacy and Allied Health Sciences, St. John's University, Jamaica, New York 11439.
Journal of Analytical Toxicology
|September 1, 1991
Summary
Forensic toxicology labs show reliable carboxyhemoglobin analysis, but cyanide testing results varied significantly. Blind check samples revealed inconsistencies in fire-related analyte determination across 10 laboratories.
Area of Science:
- Forensic Toxicology
- Analytical Chemistry
Background:
- Global performance evaluation of fire-related analyte determination is crucial.
- Standardized testing is needed for forensic toxicology laboratories.
Purpose of the Study:
- To assess the accuracy and reliability of carbon monoxide (carboxyhemoglobin) and cyanide measurements by 10 forensic toxicology laboratories.
- To identify potential discrepancies in the determination of these fire-related analytes.
Main Methods:
- A blind check sample analysis program was implemented.
- Laboratories analyzed calibrators and unknown samples for carbon monoxide and cyanide.
- Analyte stability was validated using gas chromatography, CO-oximetry, and ion chromatography.
Main Results:
- Carboxyhemoglobin analysis showed high correlation (0.986) with validation concentrations, indicating reliable results.
- Cyanide analysis yielded a lower correlation (0.443), with reported false negatives and positives.
- Variability in performance was observed across participating laboratories for both analytes.
Conclusions:
- Forensic toxicology laboratories are likely to generate reliable carboxyhemoglobin data.
- Significant challenges and inconsistencies exist in the accurate determination of cyanide in forensic settings.
- Further standardization and quality control measures are recommended for cyanide analysis.