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Updated: Jun 21, 2026

Detection and Isolation of Apoptotic Bodies to High Purity
Published on: August 12, 2018
Detection of apoptosis in mammalian development
Lin Lin1, Carlos Penaloza, Yixia Ye
1Medarex Inc, Bloomsbury, NY, USA.
Abstract:
Mammalian development is dependent on an intricate orchestration of cell proliferation and death. Deregulation in the levels, localization, and type of cell death can lead to disease and even death of the developing embryo. The mechanisms involved in such deregulation are many; alterations and or manipulations of these can aid in the detection, prevention and possible treatments of any effects this de-regulation may have. Here we describe how cell death can be detected during mammalian development, using diverse staining and microscopy methods, while taking advantage of the advancements in cell death mechanisms, derived from biochemical and teratological studies in the field.
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