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Two fatalities involving haloperidol.

B S Levine¹, S C Wu, B A Goldberger

¹Office of the Chief Medical Examiner, State of Maryland, Baltimore 21201.

Journal of Analytical Toxicology

|September 1, 1991

Summary

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Postmortem toxicology identified haloperidol in two cases, one suicidal overdose and one natural death. This study details haloperidol and reduced haloperidol concentrations in various tissues, aiding forensic analysis.

Area of Science:

Forensic Toxicology
Pharmacology

Background:

Haloperidol is an antipsychotic medication.
Accurate postmortem toxicological analysis is crucial for determining cause of death.

Observation:

Two cases involving haloperidol in postmortem analysis are presented.
Case 1: Suicidal overdose with high haloperidol and reduced haloperidol blood concentrations (1.9 and 1.4 mg/L).
Case 2: Suspected natural cardiac death with lower haloperidol blood concentration (0.6 mg/L).

Findings:

Detailed tissue distribution (bile, liver, kidney, urine) of haloperidol and its metabolite, reduced haloperidol, is provided for both cases.
Concentrations varied significantly between the overdose and natural death cases.
Elevated levels of haloperidol and reduced haloperidol were observed in the overdose case across all analyzed tissues.

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Implications:

Provides reference concentrations for haloperidol and reduced haloperidol in postmortem samples.
Aids forensic toxicologists in interpreting haloperidol levels in death investigations.
Contributes to understanding haloperidol pharmacokinetics in postmortem settings.