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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

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Related Experiment Video

Updated: Jun 21, 2026

Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

Kidney transplantation in the elderly.

Neeraj Singh1, Uday Nori, Todd Pesavento

  • 1Division of Transplantation, Department of Nephrology, The Ohio State University Medical Center, Columbus, Ohio 43210, USA. neeraj.singh@osumc.edu

Current Opinion in Organ Transplantation
|July 18, 2009
PubMed
Summary

Kidney transplantation in elderly patients faces challenges like organ shortage and evolving policies. New allocation systems may benefit younger recipients, but impact on older recipients requires further study.

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Last Updated: Jun 21, 2026

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18:48

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Published on: July 10, 2009

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11:47

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Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry
07:58

Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry

Published on: August 21, 2020

Area of Science:

  • Nephrology
  • Transplantation Medicine
  • Geriatric Medicine

Background:

  • Kidney transplantation is crucial for elderly patients with end-stage renal disease.
  • Organ shortage and policy changes necessitate a review of current practices for elderly kidney transplant recipients.

Purpose of the Study:

  • To review current kidney transplantation practices for elderly patients.
  • To evaluate the impact of proposed changes in organ allocation policies on elderly recipients.
  • To identify challenges and future directions in elderly kidney transplantation.

Main Methods:

  • Review of recent outcome data.
  • Analysis of proposed kidney allocation system changes.
  • Discussion of implications for elderly recipients.

Main Results:

  • A new kidney allocation system is proposed in the USA, focusing on age-matched allocation.
  • This system may benefit younger recipients but raises concerns for elderly recipients receiving older donor kidneys.

Conclusions:

  • Despite improved outcomes, significant challenges persist for elderly kidney transplantation.
  • These include organ shortage, low transplant rates, policy evolution, high wait-list mortality, and nonstandardized immunosuppression.
  • Prospective studies are essential to evaluate strategies and the impact of the proposed allocation system.