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Updated: Jun 21, 2026
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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
A short, economical synthesis of 2-methoxyestradiol, an anticancer agent in clinical trials
Yuqing Hou1, Cal Y Meyers, Mercy Akomeah
1Meyers Institute for Interdisciplinary Research in Organic and Medicinal Chemistry, and Department of Chemistry and Biochemistry, MC 4409, Southern Illinois University, Carbondale, Illinois 62901, USA. houyq@siu.edu
The Journal of Organic Chemistry
|July 21, 2009
Abstract:
2-Methoxyestradiol, a natural metabolite of estradiol and potential therapeutic agent for many types of cancers, has been synthesized successfully in three steps, starting from estradiol and cumyl methyl peroxide.