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[Infection with Serratia marcescens in newborn infants. Clinical aspects, therapy and disease course]
J W Scharf1, F Wild, J P Guggenbichler
1Klinik mit Poliklinik für Kinder und Jugendliche der Universität Erlangen-Nürnberg.
Abstract:
Until the 1950's Serratia marcescens was generally considered as non-pathogenic for humans. Since then the organism has been reported repeatedly as a cause of nosocomial infections. The major clinical concern about Serratia marcescens is its implication in epidemic infections and its resistance to usual antibiotics causing therapy to be difficult. We report the occurrence of Serratia marcescens as the cause of severe septicemia in three premature infants. Two infants showed a severe course of sepsis, the third infant suffered from additional meningitis and a brain abscess. All infants survived, but only one had no sequela.
Insights
Serratia marcescens, once considered non-pathogenic, now causes serious hospital infections. This study details severe sepsis cases in premature infants due to this antibiotic-resistant bacterium.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Neonatology
Background:
- Serratia marcescens was historically viewed as non-pathogenic.
- It has since emerged as a significant cause of nosocomial infections.
- Clinical concerns include epidemic potential and antibiotic resistance.
Observation:
- Three premature infants developed severe septicemia caused by Serratia marcescens.
- Two infants experienced severe sepsis, while the third had meningitis and a brain abscess.
- All infants survived the infection.
Findings:
- Serratia marcescens can cause severe, life-threatening infections in vulnerable populations like premature infants.
- The bacterium's resistance to antibiotics complicates treatment and increases the risk of severe outcomes.
- Neurological complications, such as meningitis and brain abscess, can occur.
Implications:
- Highlights the evolving pathogenicity of Serratia marcescens in healthcare settings.
- Underscores the need for vigilant surveillance and effective antibiotic strategies against resistant strains.
- Emphasizes the critical risks of nosocomial infections in neonatal intensive care units.