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Related Experiment Videos

[Herpes simplex encephalitis in childhood].

B Schlüter1, G G Aguigah, G E Bürk

  • 1Neuropädiatrische Abteilung der Vestischen Kinderklinik, Datteln.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

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Early acyclovir treatment for herpes simplex encephalitis (HSE) in children is crucial. Prompt antiviral therapy, even before serological confirmation, can improve outcomes in pediatric HSE cases.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Virology

Background:

  • Herpes simplex encephalitis (HSE) is a severe neurological condition in children.
  • Diagnosis and timely treatment are critical for patient outcomes.

Observation:

  • This report details the diagnostic and therapeutic experience with 6 pediatric patients (3 weeks to 6.3 years) suffering from HSE.
  • Clinical presentations included fever, drowsiness, and seizures.
  • Brain imaging (CT scan) and serological tests (IgM-specific HSV antibodies) were used for diagnosis.

Findings:

  • Acyclovir therapy was initiated at various stages of illness, from day 4 to day 17.
  • Four children treated with acyclovir survived but had severe neurological sequelae.
  • Two children, treated with acyclovir on day 7, survived without apparent defects, presenting with tongue vesicles initially.

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  • One patient experienced a relapse of encephalitis 5 weeks after initial treatment.

    • Implications:

    • HSE should be suspected in children with characteristic symptoms like fever, drowsiness, and seizures.
    • Antiviral therapy with acyclovir should be initiated promptly, without solely relying on serological findings.
    • Early intervention may influence the severity of neurological sequelae in pediatric HSE.