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Updated: Jun 21, 2026

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
Published on: June 11, 2015
Model-based evolutionary analysis: the natural history of phage-shock stress response
Maxime Huvet1, Tina Toni, Hui Tan
1Division of Molecular Biosciences, Imperial College London, Centre for Bioinformatics, South Kensington, London SW7 2AZ, UK.
Abstract:
The evolution of proteins is inseparably linked to their function. Because most biological processes involve a number of different proteins, it may become impossible to study the evolutionary properties of proteins in isolation. In the present article, we show how simple mechanistic models of biological processes can complement conventional comparative analyses of biological traits. We use the specific example of the phage-shock stress response, which has been well characterized in Escherichia coli, to elucidate patterns of gene sharing and sequence conservation across bacterial species.
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