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Updated: Jun 21, 2026

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
Published on: October 19, 2021
Evolution in protein interaction networks: co-evolution, rewiring and the role of duplication
David L Robertson1, Simon C Lovell
1Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK. david.robertson@manchester.ac.uk
Abstract:
Molecular function is the result of proteins working together, mediated by highly specific interactions. Maintenance and change of protein interactions can thus be considered one of the main links between molecular function and mutation. As a consequence, protein interaction datasets can be used to study functional evolution directly. In terms of constraining change, the co-evolution of interacting molecules is a very subtle process. This has implications for the signal being used to predict protein-protein interactions. In terms of functional change, the 'rewiring' of interaction networks, gene duplication is critically important. Interestingly, once duplication has occurred, the genes involved have different probabilities of being retained related to how they were generated. In the present paper, we discuss some of our recent work in this area.
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