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Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

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Published on: March 25, 2016

Idiopathic lymphoplasmacellular mucositis-dermatitis.

William K Brix¹, Sarah R Nassau, James W Patterson

¹Department of Pathology, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

Journal of Cutaneous Pathology

|July 21, 2009

Summary

Zoon-like lesions (ZLL) share similar histopathologic features across various locations. Researchers propose a new unifying term, idiopathic lymphoplasmacellular mucositis-dermatitis, for these diverse conditions.

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Area of Science:

Dermatopathology
Histopathology

Background:

Zoon described plasma-cell infiltrates in the glans penis in 1952.
Similar Zoon-like lesions (ZLL) have been identified on external genitalia and in airways.
Over 20 different names currently exist for these Zoon-like lesions.

Purpose of the Study:

To analyze histopathologic features of Zoon-like lesions (ZLL).
To propose a unified nomenclature for ZLL across different anatomical sites.

Main Methods:

Evaluation of 28 cases of ZLL, 22 of lichen planus, 8 of plasmacytoma, and 2 of syphilis.
Tabulation of 24 histologic data points per case, including epidermal and dermal features.

Main Results:

Histopathologic findings in ZLL were consistent across various locations.
Key features included superficial erosions, basal vacuolar alteration, and lozenge-shaped keratinocytes.
Dermal findings revealed dense plasma cell infiltrates, neutrophils, lymphocytes, and upper dermal fibrosis.

Conclusions:

A lack of uniform nomenclature for Zoon-like lesions (ZLL) currently exists.
The term 'idiopathic lymphoplasmacellular mucositis-dermatitis' is proposed.
This designation is morphologically descriptive and applicable to skin and mucosal surfaces.