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Related Experiment Video

Updated: Jun 21, 2026

An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans
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Ethanol preference in C. elegans.

J Lee1, C Jee, S L McIntire

  • 1Ernest Gallo Clinic and Research Center, Department of Neurology, Programs in Neuroscience and Biomedical Science, University of California, San Francisco, Emeryville, CA 94608, USA.

Genes, Brain, and Behavior
|July 21, 2009
PubMed
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Caenorhabditis elegans exhibits ethanol preference after prolonged exposure, demonstrating its utility in studying chronic ethanol effects. Dopamine and serotonin are crucial for developing this behavioral plasticity.

Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Genetics

Background:

  • Caenorhabditis elegans possesses a simple nervous system ideal for studying behavioral plasticity.
  • Acute ethanol exposure affects C. elegans behaviors, and chronic exposure induces tolerance.
  • Ethanol tolerance in mammals is linked to preference and dependence.

Purpose of the Study:

  • To establish C. elegans as a model for chronic ethanol exposure effects.
  • To investigate the development of ethanol preference in C. elegans.
  • To identify neurochemical pathways involved in ethanol preference.

Main Methods:

  • Developed a novel behavioral assay to test ethanol preference after prolonged exposure.
  • Utilized wild-type and mutant C. elegans strains (cat-2, tph-1).

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Last Updated: Jun 21, 2026

An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans
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Published on: April 9, 2015

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  • Quantified ethanol preference following different durations of ethanol pre-exposure.

    • Main Results:

    • C. elegans shows aversive responses to ethanol at baseline.
    • Animals develop ethanol preference after 4 hours of pre-exposure.
    • Ethanol preference is significantly enhanced after a lifetime of exposure.
    • Mutants deficient in dopamine (cat-2) or serotonin (tph-1) synthesis show impaired ethanol preference development.

    Conclusions:

    • C. elegans is a valuable model for studying chronic ethanol exposure and preference.
    • Dopamine and serotonin signaling are essential for ethanol preference plasticity in C. elegans.
    • This study elucidates key neurochemical mechanisms underlying ethanol-related behaviors.