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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Videos

Malignant eccrine spiradenoma: a new case report.

Ehsen Ben Brahim1, Mehdi Sfia, Monia Tangour

  • 1Department of Pathology, Mohamed Tahar Mamouri Hospital, Nabeul, Tunisia. benbrahim_ehsen@yahoo.fr

Journal of Cutaneous Pathology
|July 21, 2009
PubMed
Summary
This summary is machine-generated.

Malignant eccrine spiradenoma, a rare skin tumor, can develop from benign forms. Early detection and thorough sampling are crucial for accurate diagnosis and treatment of this low-grade malignancy.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Malignant eccrine spiradenoma is an exceedingly rare skin neoplasm originating from sweat glands.
  • It typically arises from a pre-existing benign eccrine spiradenoma.

Observation:

  • A case report details a 75-year-old male with malignant eccrine spiradenoma on his right shoulder.
  • The tumor, measuring 6 cm, presented as a recurrent mass with both benign and low-grade malignant components, including extensive necrosis and cylindromatous features.

Findings:

  • Histopathological examination revealed variable morphological differentiation, with some areas showing a near-complete loss of eccrine differentiation.
  • The presence of both benign and malignant components underscores the importance of extensive sampling.

Implications:

  • Accurate diagnosis of malignant eccrine spiradenoma necessitates thorough histopathological evaluation, including extensive sampling to identify any antecedent benign component.
  • Inadequate sampling may lead to missed diagnosis of malignant transformation.