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Related Experiment Video

Updated: Jun 21, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
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The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

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Nodal blue nevus: a pitfall in lymph node biopsies.

Lindsey Dohse1, Tammie Ferringer

  • 1Department of Dermatology, Geisinger Medical Center, Danville, PA 17822, USA. ladohse@geisinger.edu

Journal of Cutaneous Pathology
|July 21, 2009
PubMed
Summary

Benign melanocytic proliferations, including rare nodal blue nevi, can occur in sentinel lymph nodes of melanoma patients. Distinguishing these benign lesions from metastatic melanoma is crucial for accurate diagnosis and treatment.

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Area of Science:

  • Pathology
  • Dermatology
  • Oncology

Background:

  • Sentinel lymph node biopsy is a standard procedure for melanoma staging.
  • Benign melanocytic proliferations within lymph nodes are uncommon findings.

Observation:

  • A 72-year-old female melanoma patient presented with a pigmented, spindled melanocytic proliferation in the sentinel lymph node capsule extending into trabeculae.
  • This finding represents a benign nodal nevus, a rare entity.

Findings:

  • Nodal blue nevi are particularly rare and must be differentiated from metastatic melanoma.
  • Key diagnostic features include distribution within the node, specific morphologic characteristics, and immunohistochemistry.
  • Immunohistochemistry plays a vital role in distinguishing benign nevi from malignant melanoma.

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Murine Bilateral Renal Lymphadenectomy
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Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

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Last Updated: Jun 21, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Implications:

  • Accurate differentiation of benign nevi from metastatic melanoma is critical for appropriate patient management.
  • Understanding the occurrence of benign melanocytic lesions in lymph nodes can prevent misdiagnosis.
  • This case highlights the importance of meticulous histopathological examination of sentinel lymph nodes.