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Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
07:40

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

Published on: October 10, 2019

Determinants of cardiac troponin T elevation in COPD exacerbation - a cross-sectional study

Pål H Brekke1, Torbjørn Omland, Stein Harald Holmedal

  • 1Department of Medicine, Akershus University Hospital, Lørenskog, Norway. pal.brekke@medisin.uio.no

BMC Pulmonary Medicine
|July 21, 2009
PubMed

Insights

Elevated cardiac troponin T (cTnT) in COPD exacerbations is linked to higher mortality. Factors like increased neutrophils, creatinine, and heart rate, along with decreased hemoglobin, are associated with cTnT elevation.

Area of Science:

  • Cardiology
  • Pulmonology
  • Biomarkers

Background:

  • Elevated cardiac troponin T (cTnT) during COPD exacerbations correlates with increased one-year mortality post-discharge.
  • Factors influencing cTnT levels in COPD exacerbations remain largely unknown.

Purpose of the Study:

  • To identify clinical and laboratory factors associated with elevated cTnT in patients hospitalized for COPD exacerbation.

Main Methods:

  • Retrospective analysis of 441 patients admitted with COPD exacerbation (2000-2003).
  • cTnT levels measured, with elevation defined as >= 0.04 microg/l.
  • Logistic regression used to calculate odds ratios for cTnT elevation based on clinical and laboratory data.

Main Results:

  • 27% of patients (120) exhibited elevated cTnT.
  • Independent predictors of elevated cTnT included higher neutrophil count, creatinine, heart rate, and Cardiac Infarction Injury Score (CIIS).
  • Lower hemoglobin concentration was also associated with elevated cTnT.

Conclusions:

  • Multiple factors, likely reflecting comorbidities in COPD, are associated with cTnT elevation.
  • The positive association between neutrophils and cTnT suggests exaggerated inflammation during COPD exacerbations may contribute to myocardial injury.
Abstract

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