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Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

Ventricular remodeling and function: insights using murine echocardiography.

Marielle Scherrer-Crosbie¹, Baptiste Kurtz

¹Cardiac Ultrasound Laboratory, Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. marielle@crosbie.com

Journal of Molecular and Cellular Cardiology

|July 21, 2009

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Echocardiography assesses ventricular remodeling and heart failure by examining extracellular matrix (ECM) changes. This review details echocardiographic parameters in genetically modified mice to understand ECM

Area of Science:

Cardiovascular Research
Biomedical Engineering
Molecular Biology

Background:

Extracellular matrix (ECM) disturbances are critical in ventricular remodeling and heart failure development.
Genetically modified mouse models with altered ECM synthesis/degradation (MMPs, TIMPs) are key research tools.
Echocardiography offers serial evaluation of left ventricular (LV) size and function.

Purpose of the Study:

To review echocardiographic parameters for assessing ventricular remodeling and heart failure.
To detail echocardiography's application in studying LV remodeling in genetically modified mice.
To highlight potential discrepancies between echocardiographic findings and ECM modifications.

Main Methods:

Serial echocardiography to evaluate LV size and function.

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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Related Experiment Videos

Last Updated: Jun 21, 2026

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Analysis of wild-type and genetically modified mice (MMP/TIMP alterations).

Study of cardiac remodeling post-myocardial infarction and pressure overload.

Main Results:

Echocardiography provides insights into ECM-related ventricular remodeling and failure progression.
Specific echocardiographic parameters correlate with LV remodeling in MMP/TIMP models.
Discrepancies can arise between echocardiographic phenotype and ECM changes, as seen in nitric oxide synthase 3 deficient mice.

Conclusions:

Echocardiography is a valuable tool for studying ECM's role in heart failure.
Genetically modified mouse models combined with echocardiography advance understanding of cardiac remodeling.
Caution is advised when interpreting echocardiographic data in light of complex ECM interactions.