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Pediatric approach to hypertension
Tammy M Brady1, Leonard G Feld
1Division of Pediatric Nephrology, Johns Hopkins Hospital, 200 North Wolfe Street, Baltimore, MD 21287, USA. tbrady8@jhmi.edu
Insights
Pediatric hypertension (HTN) is rising, necessitating early detection and management. Secondary causes must be excluded in children diagnosed with HTN, with treatment including lifestyle changes and medication when needed.
Area of Science:
- Pediatric Cardiology
- Public Health
- Nephrology
Background:
- Pediatric hypertension (HTN) prevalence has significantly increased.
- This rise leads to more children experiencing hypertensive sequelae and contributes to adult HTN.
- Increased HTN in children presents a growing public health concern requiring vigilant management.
Purpose of the Study:
- To emphasize the need for thorough screening, diagnosis, evaluation, and treatment of pediatric HTN.
- To highlight the importance of excluding secondary causes of HTN in children.
- To outline diagnostic and therapeutic strategies for managing childhood HTN.
Main Methods:
- Review of diagnostic work-up for pediatric hypertension.
- Identification of common secondary causes of HTN in children (renal, renovascular, endocrine, genetic).
- Guidelines for therapeutic lifestyle changes and pharmacologic treatment.
Main Results:
- Primary HTN is increasingly common in children but should be a diagnosis of exclusion.
- Secondary causes of HTN are more likely in younger children and with severe BP elevation.
- Genetic disorders can cause severe, early-onset HTN.
Conclusions:
- All children with HTN require therapeutic lifestyle changes.
- Medication is indicated for symptomatic, secondary, severe, resistant HTN, or end-organ damage.
- Prompt diagnosis and management are crucial for preventing long-term complications.
Abstract:
The prevalence of pediatric hypertension (HTN) has increased over the past several decades, bringing with it increased numbers of children with hypertensive sequelae such as left ventricular hypertrophy as well as greater numbers of hypertensive adults. This growing public health concern calls for vigilant screening, diagnosis, evaluation, and treatment of HTN in children. Although primary HTN has become more common in childhood and adolescence, it still should be considered a diagnosis of exclusion. As such, a diagnostic work-up should be conducted to rule out secondary causes of HTN for any child with a confirmed diagnosis of HTN. Important secondary causes of pediatric HTN include renal parenchymal, renovascular, and endocrine etiologies, and secondary HTN becomes more likely the younger the child is and the more severe the blood pressure elevation is at diagnosis. In addition, several genetic disorders have been identified in which one aberrant gene results in severe HTN, often early in life. All hypertensive children, regardless of the cause of their HTN, should be prescribed therapeutic lifestyle changes, and children with symptomatic, secondary, or severe HTN; HTN resistant to lifestyle changes; or children with evidence of end-organ damage also should be prescribed antihypertensive medications.
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