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Related Experiment Video

Updated: Jun 21, 2026

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

State-based analysis of necrotizing enterocolitis outcomes.

Yigit S Guner1, Philippe Friedlich, Choo Phei Wee

  • 1Department of Pediatric Surgery, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, 90027, USA.

The Journal of Surgical Research
|July 21, 2009
PubMed
Summary
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Necrotizing enterocolitis (NEC) disparities in outcomes are linked to patient and treatment factors, not socioeconomic status. Higher mortality occurred in surgical NEC cases and at higher-level NICU units.

Area of Science:

  • Neonatalogy
  • Pediatric Surgery
  • Public Health

Background:

  • Necrotizing enterocolitis (NEC) is a severe neonatal disease.
  • Patient and institutional factors may contribute to NEC outcome disparities.

Purpose of the Study:

  • To investigate factors influencing necrotizing enterocolitis (NEC) outcome disparities.
  • To analyze patient and hospital-level predictors of NEC mortality and length of stay.

Main Methods:

  • Analysis of the California Office of Statewide Health Planning and Development database (1999-2004).
  • Identification of infants with NEC using ICD-9-CM codes.
  • Stratification of data by birth weight, gender, race/ethnicity, treatment, socioeconomic status, and NICU level.

Main Results:

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Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
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Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Related Experiment Videos

Last Updated: Jun 21, 2026

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

  • Identified 3328 infants with NEC; overall mortality was 12.5%.
  • Male and Hispanic neonates had lower survival rates.
  • Surgical treatment and higher NICU level (IIIC) were associated with increased mortality.
  • Patent ductus arteriosus (PDA) was common and linked to surgery.

Conclusions:

  • NEC outcome disparities are multifactorial, influenced by patient and treatment factors.
  • Further research into prediction modeling, prevention, and treatment is crucial.
  • Addressing these factors can improve outcomes for this costly neonatal condition.