Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 21, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Chronic ethanol consumption induces cavernosal smooth muscle dysfunction in rats.

Fermino S Lizarte1, Mario A Claudino, Carlos R Tirapelli

  • 1Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.

Urology
|July 21, 2009
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mineralocorticoid receptors are implicated in the initial steps of the cardiorenal damage induced by ethanol.

Frontiers in cardiovascular medicine·2026
Same author

The Nephroprotective Effects of Nebivolol Against Cyclophosphamide-Induced Toxicity Occur via Antioxidant and Anti-Inflammatory Pathways.

Journal of biochemical and molecular toxicology·2026
Same author

Nebivolol Protects the Thoracic and Abdominal Aorta and Their Perivascular Adipose Tissue From the Differential Detrimental Effects of Obesity.

Fundamental & clinical pharmacology·2026
Same author

Redox Imbalance and NOS-Dependent Modulation of Superoxide in the Bladder Mucosa of Women With IC/BPS: A Preliminary Study.

Journal of cellular and molecular medicine·2026
Same author

Basal release of 6-cyanodopamine from rabbit isolated aorta and its modulation of vascular reactivity.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

Elucidating the Urothelial-Dependent and -Independent Mechanisms Involved in the Mouse Bladder Contractility Alterations by Acute Methylglyoxal Exposure.

Biomedicines·2026

Chronic ethanol consumption impairs nitric oxide (NO)-mediated relaxation in rat cavernosal smooth muscle (CSM). This endothelial dysfunction, despite increased NO synthase expression, highlights the detrimental effects of alcohol on vascular function.

Area of Science:

  • Urology
  • Physiology
  • Pharmacology

Background:

  • Nitric oxide (NO) plays a crucial role in regulating smooth muscle function, including cavernosal smooth muscle (CSM).
  • Chronic ethanol consumption is a known risk factor for various vascular dysfunctions.

Purpose of the Study:

  • To investigate the impact of chronic ethanol consumption on NO-mediated relaxation in rat CSM.
  • To assess the effects on endothelial and smooth muscle function in the context of alcohol intake.

Main Methods:

  • Male Wistar rats were divided into control and ethanol-treated groups for 4 weeks.
  • Isometric tension measurements were performed on CSM strips.
  • Relaxation responses to acetylcholine, sodium nitroprusside (SNP), and electrical field stimulation (EFS) were evaluated.

More Related Videos

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
11:01

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

Related Experiment Videos

Last Updated: Jun 21, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats
11:01

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

Main Results:

  • Ethanol consumption significantly increased noradrenergic nerve-mediated contractions.
  • Endothelium-dependent relaxation induced by acetylcholine was significantly reduced.
  • While serum testosterone decreased, endothelial NO synthase (eNOS) and inducible NO synthase (iNOS) expression increased.

Conclusions:

  • Chronic ethanol consumption leads to endothelial dysfunction in rat CSM.
  • Impaired acetylcholine-induced relaxation suggests disruption of endothelial function, despite increased eNOS and iNOS.
  • Ethanol intake negatively impacts vascular smooth muscle function, contributing to erectile dysfunction.