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Updated: Jun 21, 2026

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
Published on: April 28, 2013
Complete renal allograft calcification
Luigi Cormio1, Oscar Selvaggio, Giovanni Stallone
1Department of Urology and Kidney Transplant, University of Foggia, Foggia, Italy.
Insights
This case study details the nephrectomy of a calcified renal allograft in a patient with end-stage renal disease. An extracapsular approach was chosen to manage severe calcification, highlighting the importance of surgical technique.
Area of Science:
- Nephrology
- Urology
- Transplantation Surgery
Background:
- End-stage renal disease (ESRD) management often involves renal transplantation.
- Recurrent graft failure may necessitate repeat transplantation.
- Severe allograft calcification presents unique surgical challenges.
Observation:
- A 37-year-old ESRD patient with two prior cadaveric renal transplants presented for nephrectomy of a calcified graft.
- Computed tomography revealed complete calcification of the right renal allograft.
- Iliac vessels and other abdominal soft tissues showed no calcification.
Findings:
- An extracapsular approach for graft nephrectomy was selected.
- This technique aimed to prevent leaving calcified capsule fragments and facilitate separation from the renal parenchyma.
- Successful management of a severely calcified renal allograft was achieved.
Implications:
- Preoperative imaging is crucial for planning complex graft nephrectomies.
- Surgeons must be proficient in both extracapsular and intracapsular nephrectomy techniques.
- This case underscores strategies for managing challenging calcified renal allografts, optimizing outcomes for subsequent transplantation.
Abstract:
A 37-year-old man with end-stage renal disease, despite having received cadaveric renal transplants in 1991 and 1997, was scheduled for nephrectomy of 1 graft before rescheduling him for a third renal transplant. Computed tomography showed complete calcification of right renal allograft, with no calcification of iliac vessels or other abdominal soft tissue. An extracapsular approach was elected to avoid leaving a calcified renal capsule and troubles in cleaving it from renal parenchyma. Preoperative imaging and familiarity with both extra- and intracapsular technique of graft nephrectomy are essential for urologists called upon to perform such procedure.
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