Related Experiment Video

Updated: Jun 21, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

[Cytomegalovirus and systemic lupus: severe infection and difficult diagnosis]

L Declerck1, V Queyrel, S Morell-Dubois

  • 1Service de médecine interne et centre de référence maladie auto-immunes systémiques, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille, France.

La Revue De Medecine Interne
|July 21, 2009
PubMed
Abstract

Insights

Cytomegalovirus (CMV) infection in systemic lupus erythematosus (SLE) is serious and challenging to diagnose. Early antiviral treatment can lead to favorable outcomes, but further research is needed.

Area of Science:

  • Rheumatology
  • Infectious Diseases

Background:

  • Cytomegalovirus (CMV) reactivation is infrequently reported in patients with systemic lupus erythematosus (SLE).
  • Diagnosing CMV infection in SLE patients is challenging and often associated with poor prognosis.

Observation:

  • Three SLE patients presented with fever, polyarthritis, myocarditis, and enteritis.
  • Patients were on corticosteroids or cyclophosphamide; no significant CD4 lymphopenia was noted.
  • Diagnosis was confirmed via CMV pp65 antigenemia.

Findings:

  • Two patients experienced favorable outcomes with antiviral therapy.
  • One patient died, highlighting the potential severity of CMV infection in SLE.
  • Literature review indicates frequent pulmonary and intestinal involvement, correlating with poor prognosis.

Implications:

  • CMV infection in SLE is often severe and diagnostically difficult.
  • Risk factors, optimal treatment, and prophylaxis for CMV in SLE require further investigation.
  • Biotherapy use in SLE patients may increase the incidence of CMV infections.

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