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Updated: Jun 21, 2026

Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature
Published on: December 20, 2016
Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids
Vineet Kumar1, Sanjay V Malhotra
1Laboratory of Synthetic Chemistry, SAIC-Frederick Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Abstract:
The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.

