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Updated: Jun 21, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
No prospective association between hypotension and idiopathic fatigue
William E Lee1, Matthew Hotopf
1Department of Psychological Medicine, Institute of Psychiatry, King's College London, Weston Education Centre, London, UK. w.lee@iop.kcl.ac.uk
Objective:
To test the hypothesis that there is a prospective association between constitutional hypotension and new-onset fatigue in a large, representative sample.
Methods:
In this prospective study using a large population-based cohort dataset, the Health and Lifestyle Survey, a representative sample of the population residing in private dwellings in Great Britain in 1984 (n=9003, ages 18-97 years) had their blood pressure measured and were asked about fatigue. Participants reporting fatigue at baseline were excluded. The outcome was fatigue state in 1991.
Results:
No association was shown, unadjusted or adjusted for likely confounders, in the healthy young population [systolic BP: adj. OR (95% CIs)=1.25 (0.90-1.74); diastolic BP: 1.18 (0.84-1.65)] or the whole population [systolic BP: 0.98 (0.77-1.26); diastolic BP: 1.01 (0.79-1.26)].
Conclusion:
In this British population-based study, hypotension was not a risk factor for incident idiopathic fatigue.
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