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Related Concept Videos

Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Focusing of Light in the Eye01:16

Focusing of Light in the Eye

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Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment

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Related Experiment Video

Updated: Jun 21, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Myopia: a collagen disease?

Yin Yang1, Xiaohong Li, Naihong Yan

  • 1Department of Ophthalmology and Ophthalmic Laboratories, West China Hospital, Sichuan University, No. 1, 4th Keyuan Road, Gaopeng Avenue, Chengdu, Sichuan 610041, PR China.

Medical Hypotheses
|July 21, 2009
PubMed
Summary

Myopia, a growing global health issue, may stem from changes in scleral collagen. This review suggests alterations in scleral collagen are linked to myopia development and its underlying causes.

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Related Experiment Videos

Last Updated: Jun 21, 2026

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network
06:07

Preparing Porcine Eyes for Confocal Reflectance Microscopy to Visualize the Vitreous Collagen Fiber Network

Published on: October 17, 2025

Area of Science:

  • Ophthalmology
  • Genetics
  • Biochemistry

Background:

  • Myopia is a significant global public health concern.
  • While environmental factors like near-work are implicated, myopia pathogenesis remains unclear.
  • Heredity is considered a primary factor, potentially interacting with environmental and habitual influences.

Purpose of the Study:

  • To review the role of scleral collagen in myopia development.
  • To explore the association between scleral collagen alterations and myopia pathogenesis.
  • To hypothesize that changes in scleral collagen underlie myopia's pathological changes.

Main Methods:

  • Literature review of myopia research.
  • Medline database search for relevant articles.
  • Analysis of studies linking scleral collagen to myopia.

Main Results:

  • Recent research highlights the importance of scleral collagen in myopia development.
  • Changes in scleral collagen are associated with pathogenetic factors of myopia, including inheritance.
  • Evidence suggests scleral collagen alterations are linked to myopia's underlying mechanisms.

Conclusions:

  • Myopia may be a disorder characterized by alterations in scleral collagen.
  • Scleral collagen changes are hypothesized to be responsible for pathological changes observed in myopia.
  • Further research into scleral collagen's role is warranted for understanding myopia.