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Updated: Jun 21, 2026

Quantification of Atherosclerosis in Mice
Published on: June 12, 2019
The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis
David Engel1, Tom Seijkens, Marjorie Poggi
1Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands.
Abstract:
Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful co-stimulatory dyads, the CD154 (also known as CD40 ligand, CD40L)-CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed.
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