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Updated: Jun 21, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Nitrosative and oxidative stress responses in fungal pathogenicity
Alistair J P Brown1, Ken Haynes, Janet Quinn
1School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK. al.brown@abdn.ac.uk
Abstract:
Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees of evolutionary adaptation to their human host. Not surprisingly, these fungal pathogens display differing degrees of resistance to the reactive oxygen and nitrogen species used by human cells to counteract infection. Furthermore, whilst evolutionarily conserved regulators, such as Hog1, are central to such stress responses in many fungal pathogens, species-specific differences in their roles and regulation abound. In contrast, there is a high degree of commonality in the cellular responses to reactive oxygen and nitrogen species evoked in evolutionarily divergent fungal pathogens.
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